S. S. Sonar, Sandip A. Sadaphal, Vilas B. Labade
Dec 28, 2009
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Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract
An efficient synthesis of novel α-aminophosphonates by the reaction of quino[2,3-b][1,5]benzoxazepines with triethyl phosphite in the presence of the easily available, inexpensive, and nontoxic catalyst p-toluene sulphonic acid (p-TSA). This method affords the α-aminophosphonates under the influence of ultrasound irradiation in solvent-free conditions, in short reaction times (4–6 min), high yields (80–90%), with improved purity. The synthesized α-aminophosphonates show antibacterial activity against Gram-positive and Gram-negative bacteria. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.