H. Dogan, A. Duran, S. Rollas,
Nov 1, 2005
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0
Influential Citations
17
Citations
Journal
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry
Abstract
The compounds 1H-4,5-dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-1,2,4-triazoline-5-thiones have been synthesised from 3-hydroxy-2-naphthoic acid hydrazide in two steps. The structural elucidation of the synthesised compounds has been performed by 1 H NMR and mass spectroscopic data besides elemental analyses. Some of the compounds are tested in vitro for their ability to inhibit growth of 60 different human cancer cell lines by the National Cancer Institute and notable cytotoxic effect on some cancer cell lines is observed from some of them as expected in comparison with the control agent 5-fluorouracil.