A. Atta, E. Abdel‐Latif
Mar 1, 2021
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0
Influential Citations
3
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Journal
Russian Journal of General Chemistry
Abstract
Abstract New 4-acetyl-5-anilino- N -arylthiophene-2-carboxamide derivatives have been synthesized by reaction of 2-acetyl-3-oxo- N -phenylbutanethioamide with three different chloroacetamide reagents. The synthesized thiophenes have been used as precursors in preparation of various thiazole-thiophene hybrids via their condensation with thiosemicarbazide and following treatment of the corresponding thiosemicarbazone with chloroacetone and/or chloroacetic acid. The reaction of 4-acetyl-5-anilinothiophenes with DMF–DMA or malononitrile is the synthetic route to the targeted thieno[2,3- b ]pyridine derivatives. Molecular structures of the synthesized compounds have been determined on the basis of IR, 1 H and 13 C NMR, and mass spectra. The synthesized thiophene-based compounds have been tested for in vitro cytotoxicity by the MTT assay using 5-flourouracil as a reference drug. Thiophene-2-carboxamide derivatives exhibit good inhibitory activity against four cell lines, especially those products that contain thiazolidinone ring or thiosemicarbazide moiety in their structures.