G. Mohan, G. Sridhar, E. Laxminarayana
Sep 1, 2021
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Journal
Russian Journal of Organic Chemistry
Abstract
A series of N-[2-(4-methoxyanilino)-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]benzamides have been synthesized, and their structure was confirmed by 1H and 13C NMR and mass spectral data. The synthesized compounds were tested for their anticancer activity against four human cancer cell lines such as MCF-7 (breast), A549 (lung), DU-145 (prostate), and MDA MB-231 (breast) by MTT assay using etoposide as standard drug. All compounds showed moderate to good activity compared to the standard drug; the most potent were those containing methoxy and nitro groups in the benzamide moiety.