M. Ghorab, F. Ragab, E. Noaman
Feb 1, 2009
Citations
0
Influential Citations
8
Citations
Quality indicators
Journal
Arzneimittelforschung
Abstract
Abstract Various isomeric structural purine analogues possessing the pyrazolo[3,4-d]pyrimidine nucleus bearing amino acid moieties have been synthesized. The structures of the synthesized compounds were elucidated by spectral data. Preliminary testing for in vitro anticancer activity of the synthesized compounds against Ehrlich ascites carcinoma cells was carried out. 2-(1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-propanoic acid (3b), 4-methyl-2-(1-phenyl-1H-pyrazolo[3,4-d] pyrimidin-4-ylamino)-pentanoic acid (3d), 4-methylthio-2-( 1-phenyl- 1H-pyra-zolo[3,4-d] pyrimidin-4-ylamino)-butanoic acid (3e) and phenyl-2-(1-phenyl-1H-pyrazolo[3,4-d] pyrimidin-4-ylamino)-propanoic acid (3f) were the most active compounds. Moreover, compounds 3e and 1-( 1-phenyl-1H-pyrazolo[3,4-d] pyrimidin-4-yl)-pyrrolidine-2-carboxylic acid (4) exhibited significant in vivo radioprotective activity.