Liao Shang-ten
2014
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Influential Citations
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Citations
Quality indicators
Journal
Chinese Journal of Synthetic Chemistry
Abstract
Ten novel ADP receptor antagonists,2-acetoxy-5-[2-oxo-2-( 4-substitutedpiperazin-1-yl) ] ethyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine( 4a ~ 4j),were designed and synthesized from 5,6, 7,7a-tetrahydrothieno[3,2-c]pyridine-2( 4H)-one hydrochloride in yield of 51% ~ 72%. The structures were characterized by1H NMR,IR and HR-MS. Primary biological activity test indicated that 4a ~ 4j exhibited certain anti-clotting activities. 4g,4i and 4j were significantly better than that of positive control drug Ticlopidine. Their growth rates of clotting time on rats were 43. 5%,71. 8% and 58. 0%,respectively.