Rajesh Vishnoi, M. Sabir, Mahesh Gupta
Aug 28, 2015
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Journal
Asian Journal of Research in Chemistry
Abstract
A number of aldehydes and ketones were condensed with 2, 4-dinitro phenyl hydrazine to give corresponding 2, 4-dinitrophenyl hydrazones (Ia-Ic). Again aldehydes and ketones were reacted with 2-phenylacetohydrazide to give hydrazide-hydrazones (IIa-IIc). Structure of synthesized compounds were confirmed by elemental analysis and spectral data. The synthesized compounds were evaluated for anticonvulsant activity in maximial electroshock seizure (MES) test using phenytoin as standard drug. In which compound IIa was found most potent among the series.