A. Foroumadi, S. Tabatabai, G. Gitinezhad
2000
Citations
0
Influential Citations
13
Citations
Quality indicators
Journal
Pharmacy and Pharmacology Communications
Abstract
5-Aryl-1,3,4-thiadiazole derivatives were synthesized and tested for anticonvulsant activity using the pentylenetetrazole-induced lethal convulsion test. The results showed that 2-amino derivatives have anticon vulsant activity (LD50 > 500mg kg−1) and this effect was not mediated through benzodiazepine receptors. The fluoro electron-withdrawing substituent on the phenyl ring did not potentiate the activity of the compounds.