R. Gitto, M. Barreca, Eleonora Francica
Mar 10, 2004
Citations
0
Influential Citations
11
Citations
Journal
Arkivoc
Abstract
Following our previous molecular modeling studies we herein report the synthesis of substituted 1,2,3,4-tetrahydroisoquinolinone-4-carboxylic acids in an attempt to obtain new anticonvulsants acting as negative modulators of AMPA-type glutamate receptor. The evaluation of their pharmacological effects demonstrated that some derivatives were able to prevent audiogenic induced seizures in DBA/2 mice.