Guo Ya-nan
2010
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Journal
Journal of University of South China
Abstract
3-methyl-2-(3-chlorophenyl) morpholinhy drochloride was synthesized from 1-(3-chlorophenyl)-2-bromo-1-Acetone and ethanolamine as raw material,in polar solvents by amine,cyclization reaction,reduction,at last acidification by divergent synthetic method,and the yield is 79.3%.The target compound structure was confirmed by IR,1H NMR,MS tec-hnology,and the synthesis of this compound had never been reported at home and abroad.Using the forced swim mice model of antidepressant pharmacology,the pharmacological effects of antidepressant of the synthesized compounds were observed.That compound(2) have potent antidepress activities,and are worth further development.