A. A. O. Abeed, M. Youssef, Rehab R Hegazy
Nov 1, 2017
Citations
2
Influential Citations
17
Citations
Journal
Journal of the Brazilian Chemical Society
Abstract
A new series of benzazole, thiazolidinone and azetidin-2-one derivatives incorporating to pyrazole moiety were synthesized by condensation of 1,3-diphenyl-1H-pyrazol-4-carboxaldehyde with different nucleophiles. The structures of the newly synthesized compounds were confirmed by analytical and spectral methods. Some of these compounds were evaluated for their antihyperglycemic and renoprotective activities. Three compounds showed remarkable anti-diabetic potency, whereas other five compounds showed significant renoprotective activity.