N. Sharma, T. Aggarwal, S. Bhati
2010
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Journal
Oriental journal of chemistry
Abstract
D-5-Amino-5-carboxy-valeramido)-3-(acetylhydrazido)-8-oxo-5-thio-1-azabicyclo (4,2,0)-oct- 2-ene-2-carboxylic acid (1). 7-(D-5-Amino-5-carboxy-valeramido)-3-(substitutedarylacetylhydrazido)- 8-oxo-5-thio-1-azabicyclo(4,2,0)-oct-2-ene-2-carboxylic acid.(2-5). 7-(D-5- Amino-5- carboxy- valeramido)- 3- (2'- substituted aryl-3'-chloro-4'-oxo-azetidin-1'-yl)-acetylamino)-8-oxo-5-thio-1- azabicyclo(4,2,0)-oct-2-ene-2-carboxylic acid (6-9). 7-(D-5- Amino-5- carboxy- valeramido)- 3-((2'- substitutedaryl-4'-oxo-thiazolidin-3'-yl)-acetyl amino)- 8-oxo- 5-thio- 1-azabicyclo (4, 2, 0)- oct-2-ene- 2- carboxylic acid.(10-13) have been synthesized in present study. All the developed congeners of cephalosporin acid evaluated for their antibacterial and antifungal activity. Compound 11 was found to possess potent bactericidal activity in comparison to clinically used chemotherapeutic agents viz. ampicillin; norfloxacin and fluconazole.