K. Sujatha, Shilpa, R. Gani
May 16, 2019
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Journal
International Research Journal Of Pharmacy
Abstract
In this study,1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone was synthesized by reacting p-chloroaniline with ethyl trifluroacetate in presence of n-butyl lithium, further reacting with ammonium thiocyanate with hydrochloric acid leads to 1-(4-chloro-2-(2,2,2-trifluoroacetyl)phenyl)urea. Then reacted with ArCOCH2Br and sodium acetate gave 1-{5-chloro-2[(4-substituted-1, 3-thiazol-2-yl) amino] phenyl}-2,2,2-trifluroethanone derivatives. The chemical structure of newly synthesized compounds has been confirmed on the basis of elemental analysis, IR, 1H NMR and Mass spectral data. The newly synthesized compounds were screened for their antibacterial activity invitro against Gram-positive bacteria namely Escherichia coli, Staphylococcus aureus, and Gram-negative bacteria namely Pseudomonas aeruginosa, Bacillus subtilis and the fungus namely Candida albicans by disc diffusion method. Among the synthesized compounds 5b, 5f, 5g, 5h, 5j were found to have a very good antibacterial and antifungal activity.