E. Pomarnacka
Jul 24, 2007
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Quality indicators
Journal
ChemInform
Abstract
The synthesis of 4-chloro-2-mercapto-N-(l,5-dimethyl- or 1-alkyl-1,4,5,6-tetrahydrol,2,4-triazin-3-yl)benzenesulfonamides 15-28 is described. Suggested mechanism of the investigated reaction is discussed. The compounds 15-17 and 19 were tested for their in vitro anti-HIV potency at the National Cancer Institute and only 4-chloro-2-mercapto-N-(1-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-3-yl)benzenesulfonamide (15) showed reasonable activity (TI 50 = 6.21).