L. Labanauskas, A. Brukštus, P. Gaidelis
Feb 1, 2001
Citations
0
Influential Citations
0
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
Recently [1], compounds combining antiinflammatory activity and low toxicity were found among 2-bromine-substituted derivatives of 5,6-dialkoxybenzophenone. It is known that the antiinflammatory activity is also inherent in 3,4-dialkoxychalcones [2, 3] and that the activity of 3,4-dialkoxybenzophenones and 3,4-dialkoxychalcones (their vinylogs) exhibit a similar character [3, 4]. In this context, it was of interest to synthesize and characterize a series of new 3-aryl-1-(8-bromo-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)2-propen-1-ones (Ia – Ii) with the formula