V. Magrioti, D. Hadjipavlou-Litina, V. Constantinou-Kokotou
Feb 10, 2003
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Influential Citations
13
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
The synthesis of optically pure long-chain 2-amino-alcohols and 1-O-dodecyl-2-deoxy-2-amino-sn-glycerol was carried out starting from L- or D-Boc-Ser(OBn)-ol by oxidation and consecutive Wittig reaction or etherification reaction. 2-Amino-oleyl alcohol was synthesized by reduction of the corresponding 2-amino-oleic acid. All the long chain amino-alcohols presented interesting inhibition of carrageenin-induced paw edema in rats (ED(50) from 0.017 to 0.010 mmol/kg).