S. Mokale, S. S. Shinde, Rupali D. Elgire
Aug 1, 2010
Citations
1
Influential Citations
77
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives has been synthesized by condensation of thiourea, 5-(4-subtituted phenyl)-5-oxopentanoic acid and substituted aldehyde. The synthesized compounds were screened for their anti-inflammatory activity using rat paw edema method. Most of the compounds from the series showed significant (p <0.05) anti-inflammatory activity.