T. Chaban, V. T. Foliush, V. Ogurtsov
Jul 1, 2021
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Journal
Russian Journal of Bioorganic Chemistry
Abstract
By the reaction of chloroacetamidothiazole with 5-aryltetrazoles and 5-mercaptotetrazoles 2-(5-aryltetrazol-2-yl)- and 2-(1H-tetrazol-5-ylsulfanyl)-N-thiazol-2-ylacetamides were prepared. The study of the anti-inflammatory properties of the synthesized compounds was carried out. Compounds have been identified, whose activity exceeds the reference drug ibuprofen. Molecular docking to cyclooxygenase-1 and cyclooxygenase-2 was carried out and it was shown that 2-[1-(2,5-dimethylphenyl)-1H-tetrazol-5-ylsulfanyl]-N-thiazol-2-ylacetamide has the highest affinity for the active center of the cyclooxygenase.