Zh. S. Arustamyan, R. E. Margaryan, A. A. Aghekyan
Feb 1, 2021
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Journal
Russian Journal of Organic Chemistry
Abstract
5-(Tetrahydro-4-phenyl-2H-pyran-4-yl)-4H-1,2,4-triazole-3-thiol was synthesized by the reaction of 4-phenyltetrahydropyran-4-carbonyl chloride with thiosemicarbazide and subsequent cyclization of the resulting amide in the presence of KOH. The condesation of the synthesized thiol with arylmethyl chlorides and amidomethyl halides gave S- and S,N-substituted triazole derivatives. The synthesized compounds were tested for anti-inflammatory activity.