M. Hemdan
Feb 23, 2010
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Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract
2-Furoyl isothiocyanate (1) is used as a building block in synthesizing different heterocyclic systems of anticipated biological activities. Thus, isothiocyanate 1 was reacted with different nucleophilic reagents to produce five- and six-membered heterocyclic systems such as 1,2,4-triazoline, thiadiazolidine, quinazoline, benzothiazole, benzoxazole, benzimidazole, thiazolidine, and imidazolidine. The structures of all the synthesized compounds were confirmed by microanalytical and spectral data. The antimicrobial activity of some of the synthesized compounds was tested. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.