N. Siddiqui, M. Idrees, N. Khati
2013
Citations
0
Influential Citations
9
Citations
Journal
South African journal of chemistry
Abstract
The synthesis of novel derivatives of pyrazole-3-carboxylate (3–5) from methyl 4-(benzofuran-2-yl)-2,4-dioxobutanoate (1) is reported. Synthesis of substituted 1,3,4-oxadiazoles (7–11) and 5-amino pyrazole-4-carboxylate (12) derivatives starting fromthe 5-(benzofuran-2-yl)-1-phenyl-1 H -pyrazole-3-carbohydrazide (6) are also described. Twelve new compounds were synthesized and their identities have been established on the basis of elemental and spectroscopic analysis such as IR, 1 H NMR, 13 C NMR, Mass Spectra. The compounds were also screened for their antibacterial and antifungal activities against Gram-positive, Gramnegative bacteria and a fungus. KEYWORDS 2,4-Dioxobutanoate, isoxazole, pyrazoles, pyrazole-3-carbohydrazide, 1,3,4-oxadiazoles.