V. L. Gein, N. N. Kasimova, É. Voronina
Mar 1, 2001
Citations
0
Influential Citations
6
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
Previously we demonstrated that substituted 3-hydroxy3-pyrrolin-2-ones possess pharmacological activity of various types including antimicrobial [1, 2], antiinflammatory [3], and nootropic [1]. Taking into account that some of the antimicrobial agents used in medicine contain dialkylaminoalkyl groups [4], it was interesting to synthesize a series of 5-aryl-4-acyl-1-(N,N-dimethylaminoethyl)-3-hydroxy-3-pyrrolin-2-ones and study their antimicrobial properties. With a view to this synthesis, we have studied the reactions of acylpyruvic acids with a mixture of N,N-dimethylethylenediamine and an aromatic aldehyde. The results of our investigation showed that mixing equimolecular amounts of the initial reagents in warm ethyl alcohol or dioxane leads with a good yield to the formation of compounds I – XXVIII (Table 1).