V. L. Gein, A. Fedotov, T. M. Zamaraeva
Mar 1, 2013
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Journal
Pharmaceutical Chemistry Journal
Abstract
N,6-Diaryl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides were synthesized by a three-component reaction of acetoacetanilides (2,4-dimethylacetoacetanilide, o-acetoacetaniside, 2-chloroacetoacetanilide), aromatic aldehydes, and urea. The structures of the products were established by IR and PMR spectroscopy and mass spectrometry. The antimicrobial activity of the synthesized compounds was studied.