V. Horishny, V. Matiichuk
Sep 1, 2020
Citations
0
Influential Citations
0
Citations
Journal
Russian Journal of Organic Chemistry
Abstract
The reactions of 2-cyano-3-oxobutanethioamide with ethyl 3-aryl-2-bromopropanoates and dialkyl acetylenedicarboxylates afforded a combinatorial library of new 2-[5-(R-benzyl)-4-oxo-1,3-thtiazolidin-2-ylidene]-3-oxobutanenitrile and [2-(1-cyano-2-oxopropylidene)-4-oxo-1,3-thiazolidin-5-ylidene]acetic acid derivatives. The synthesized compounds were evaluated for antimicrobial activity, and the activity of some derivatives against gram-positive Staphylococcus aureus ATCC 43300 exceeded the activity of ceftriaxone taken as a reference drug.