Dundappa S. Donawade, A. Raghu, G. S. Gadaginamath
Apr 1, 2007
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0
Influential Citations
14
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Journal
ChemInform
Abstract
The exclusive formation of 1-substitutcd-6-a-oximino-ethylindoles 3a-d from the reaction of 3,6-diacetylindoles with hydroxylamine reveals the chemoselectivity of C 6 -acetyl function over that of C 3 -acetyl function towards the nucleophilic attack of hydroxylamine. These monooximes 3a-d are stirred with methanesulphonyl chloride in dry pyridine at room temperature to give the novel 5-substituted-7-acetyl-3,6-dimelhyloxazolo[4,5-f]indoles 5a-d in good yields. The structures of all these newly synthesised compounds have been confirmed by their spectral and analytical data and they have been screened for antibacterial and antifungal activities.