N. Joshi, A. Bapodra, H. Parekh
Sep 30, 1997
Citations
0
Influential Citations
0
Citations
Journal
ChemInform
Abstract
Among a wide variety of nitrogen heterocycles that have been explored for developing pharmaceuticallly important molecules, the oxadiazoles1 and imidazolinones2 have played an important role in medicinal chemistry. Furthermore, incorporation of 3,4,5-trirnethoxybenzamide moiety has been found to enhance the pharmacological activity. Therefore in the present study, we have coupled it with oxadiazole and imidazolinone moieties with a view to evaluating their antimicrobial activity. 2-Aryl-5-p-(3',4',5'trimethoxybenzamidophenyl)-1 ,3,4-oxadiazoles (2) have been prepared by the cyclocondensation of 4-(3',4',5'trimethoxybenzamido)benzoylhydrazide (1) with different aromatic acids. While -l-arylidenc-1-p-(3' ,4' ,5' -trimethoxybenzamido)benzoylamino-2-methyl-5-oxo-2-imidazoltnes (3) have been synthesised by the condensation of the latter hydrazide with azl,tctones. These compounds have been screened tor their antiiiHt:rohial activity against different strains of bacteria and tlill~l