N. Patel, Jaymin C. Patel, V. Patel
Oct 1, 2010
Citations
0
Influential Citations
3
Citations
Journal
Chinese Journal of Chemistry
Abstract
Some new derivatives 7-chloro-2-[2-(2,6-dichlorophenyl)amino]benzyl-3-[4-(2-substituted phenyl-4-oxo- thiazolidin-3-yl)phenyl]sulfonamido-quinazolin-4(3H)-ones 5a–5l were synthesized from 2-[2-(2,6-dichloro-phenyl)amino]phenyl acetic acid via acid chloride, benzoxazinone, amino quinazolin-4(3H)-one and Schiff base formation. The synthesized compounds were screened for in vitro antibacterial and antifungal activities by broth micro dilution method. Some of the Schiff base as well as 4-thiazolidinone derivatives showed promising antibacterial activity while pronounced antifungal activity was observed against C. albicans.