O. Sharma, B. Shrivastava, Rajeev K. Singla
2011
Citations
0
Influential Citations
0
Citations
Journal
Indo Global Journal of Pharmaceutical Sciences
Abstract
The aim of current research work was to synthesized some novel pyrimidine-2,4-diones by condensing various substituted amines with 3-substituted -6-chlorouracil. The structure of the synthesized compounds were characterized using physical & spectral data. Novel pyrimidine-2,4-(1H,3H)-diones were then screened for their antimicrobial profile using kirby bauer disc diffusion method. The anti-bacterial data reveals that compounds OBP01 and OBP02 had better activity against tested B. subtilis (Gram-positive) whereas OBP03 against E. coli (Gram-negative). OBP03 also found to have better anti-fungal activity than rest of the compounds when tested against Aspergillus niger & Penicillium marneffei. This study lead us to conclude that pyrimidine2,4(1H,3H)-diones are potential agents to treat infection. © 2011 IGJPS. All rights reserved.