H. S. Patel, H. Mistry, H. Desai
Jan 5, 2016
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Biosciences, Biotechnology Research Asia
Abstract
4-(4’-sulphanilyl)-1-methyl piperazine (2) has been prepared by the reaction of N-acetyl sulphanilyl chloride (ASC) with 1-methyl piperazine followed by the hydrolysis of the product with ethanolic HCl. This compound (2) under go condensation with aromatic aldehydes to give the corresponding Schiff’s base (3a-h). The Schiff’s base (3a-h) on cyclocondensation reaction with thioglycolic acid gives 4-thiazolidinones. Biological screening of the prepared compounds has been carried out on some strains of bacteria.