Abdel-Rhman B. A. El-Gazzar, H. Hafez
2008
Citations
0
Influential Citations
10
Citations
Journal
Acta Chimica Slovenica
Abstract
A novel series of 7-amino-5-aryl-6-(benzothiazol-2-yl)-2-thioxopyrido[2,3-d]pyrimidin-4-one derivatives was prepared and their reactivity towards some reagents was studied. Transformations of aromatic aldehydes, halogens and some hydrazonoyl chlorides towards the corresponding poly-condensed heterocyclic compounds, such as 8-amino-7-(benzothiazol-2-yl)-[l,3]thiazolo[4,5-a]pyrido[2,3-d]pyrimidine -3,5-diones, 3,9-diarylisoazolo[5',4':4,5]thiazolo -[3,2-a]pyrido[2,3-d]pyrimidin -10-ones and 1,6-diaryl and 3-aryl- or 3-acetyl- or 3-ethylcarboxylate- derivatives of 7-(benzothiazol-2-yl)-pyrido[2,3-d][1,2,4 ]triazolo[4,5-a]pyrimidin-5-ones were investigated. Compounds synthesized were screened in vitro for their antimicrobial activity against a variety of bacterial and fungal agents.