G. Naganagowda, B. Padmashali
Jul 30, 2010
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Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract
3-Chlorobenzothiophene-2-carbonylchloride 1 was prepared from cinnamic acid and then converted into the acid hydrazide 2. Reaction of 3-chloro-1-benzothiophene-2-carbohydrazide 2 with the appropriate isothiocyanate yielded the substituted thiosemicarbazides 3a–b, which are cyclized into thioxotetrahydropyrimidine 4a–b, 1,3,4-thiadiazoles 5a–b, thiazolidine 6a–b, 1,3,4-oxadiazole 7a–b, triazoles 8a–b, 1,2,4-triazole substitutedthioate 9a–f, and 1,3-thiazolylidenes 10a–b, respectively. The structures of the newly synthesized compounds were elucidated on the basis of elemental analyses, IR, 1H NMR, and mass spectral data and have been screened for antimicrobial and anthelmintic activities.