S. Rashmi, T. S. Kumara, C. Sandeep
Dec 31, 2014
Citations
0
Influential Citations
2
Citations
Journal
International Journal of Pharmacy and Pharmaceutical Sciences
Abstract
Objective: Synthesis, antimicrobial, antioxidant and docking studies of (3-methoxy-5-nitrobenzofuran-2-yl)(phenyl)methanone derivatives ( 2a-j) . Methods: The products 2a-j, were obtained from different (3-hydroxy-5-nitrobenzofuran-2-yl)(phenyl)methanones ref and alkyl bromides in the presence of K 2 CO 3 in DMF at room temperature. Afterwards, characterised through 1 H-NMR, [13]C-NMR, ESI-LCMS and elemental analyses. Finally, subjected them for antimicrobial and antioxidant studies through agar well diffusion technique and docking interaction studies through automated docking technique. Results: From the current procedure, the compound 2a has showed the highest antibacterial activity and 2j showed lowest antibacterial activity. None of these (2a-j) have showed antifungal activity. The compound 2d has shown highest free radical scavenging activity and 2e has shown least activity. The biological properties of the synthesised compounds (2a-j) were further supported by docking studies. Conclusion: Successfully synthesised and characterized ten individually novel (3-alkoxy-5-nitrobenzofuran-2-yl)(phenyl)methanone derivatives ( 2a-j ) in one pot procedure and studied antimicrobial, antioxidant and docking properties. Perhaps the present work provides an evidence for the preparation, antimicrobial and antioxidant properties of the novel benzofuran derivatives.