J. Vora, K. Vyas
May 1, 2019
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Journal
International Journal of Scientific Research in Science, Engineering and Technology
Abstract
An efficient synthesis of a novel compound series of 2-[3,5-bis(trifluoromethyl)phenyl]-4-(substitutedphenyl)-1,4-dihydropyrimido[1,2-a]benzimidazole (Biginelli reaction) was accomplished from (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-chlorophenyl)prop-2-en-1-one and 1H-benzo[d]imidazol-2-amine Microwave 25 minute heating after the product obtained another method Conventional 7 hrs, with 30 % KOH, Ethanol. Here (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(4-chlorophenyl)prop-2-en-1-one(Chalcone) is prepared by 1-(3,5-bis(trifluoromethyl)phenyl)ethanone and different aldehyde with Claisen-Schimidt Condensation.All the newly synthesized compounds were characterized by infrared and 1H nuclear magnetic resonance and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.