W. Hamama, M. Ibrahim, H. Raoof
Jul 1, 2017
Citations
0
Influential Citations
6
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Condensation of 2-amino-5-phenyl-5H-thiazolo[4,3-b] [1,3,4] thiadiazoles (1) with some carboxylic acid derivatives furnished corresponding compounds 2–4, respectively. Alkylation of 1 with benzoylchloride and 4-chlorobenzyl chloride afforded thiazolo[4,3-b][1,3,4]thiadiazole derivatives 5 and 6, respectively. Similarly, transformation of 1 with chloroacetyl chloride yielded chloroacetamide derivative 7. The later compound was subjected to react with potassium thiocyanate or piperazine whereby, the binary thiazolidinone derivative 8 and N1,N4-disubstituted piperazine 9 were produced, respectively. Also, the reactivity of 1 toward various active methylene reagents was investigated. Accordingly, our attempts to synthesize the tricyclic heterocyclic system 10, 11′, 12′ by reaction of 1 with chloroacetonitrile, 4-oxo-4-phenylbutanoic acid and/or diethylmalonate in presence of acetyl chloride was furnished 10, 11, and 12. The newly synthesized compounds were screened as antimicrobial agent.