K. Mogilaiah, B. Sakram
Dec 1, 2004
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0
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Journal
ChemInform
Abstract
Treatment of (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)-acetic acid hydrazide 1 with different isatins 2 affords (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)-acetic acid (2-oxo-1,2-dihydroindol-3-ylidene)hydrazides 3. Aminomethylation of 3 with formaldehyde and cyclic secondary amines furnishes (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)acetic acid (1-aminomethyl-2-oxo-1,2-dihydroindol-3-ylidene)hydrazides 4 (Mannich bases). The structural assignments to these compounds are based on their elemental analyses and spectral data. The antibacterial activity of Mannich bases 4 have been studied.