A. N. Mayekar, H. Yathirajan, B. Narayana
Jan 18, 2010
Citations
1
Influential Citations
37
Citations
Journal
International Journal of Chemistry
Abstract
A series of new 1,3,4-oxadiazole derivatives having 6-bromonaphthalene moiety are synthesized. 2-[(6-bromo-2-naphthyl)oxy]acetohydrazide was treated with various substituted aromatic acids in presence of POCl3 to give 2-{[(6-bromo-2-naphthyl)oxy]methyl}-5-aryl-1,3,4-oxadiazole. Also the hydrazide on treating with CS2/KOH gave 5-{[(6-bromo-2-naphthyl)oxy]methyl}-1,3,4-oxadiazole-2(3H)-thione, which was subjected to Mannich reaction to get a series of Mannich bases and with alkyl/aryl halide to give 2-{[(6-bromo-2-naphthyl)oxy]methyl}-5-[(alkyl/aryl)thio]-1,3,4-oxadiazole. The newly synthesized compounds were characterized by analytical and spectral data. Antimicrobial activities of these compounds were carried out and some of them have exhibited good activity.