G. S. Reddy, M. V. Reddy, C. R. Rani
2012
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0
Influential Citations
4
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Journal
Heteroatom Chemistry
Abstract
A new family of di(1-oxo/thioxoper-hydro-1λ5-[1,3,2]diazaphospholo[1,5-a]pyridine-1-yl)(4-substituted phenyl) boronates (4a–j) has been synthesized in a two-step process. A reaction of (±)-piperidin-2-yl-methanamine (1) phosphoryl/phosphorothioyl chloride in the presence of triethylamine in dry tetrahydrofuran formed the intermediate monochloride (2), which on condensation with p-substituted phenylboronic acids (3a–j) afforded the titled compounds (4a–j). They were characterized by elemental, IR, 1H, 13C, 31P NMR, and mass spectral analyses. All these compounds showed moderate to high antiosteoclast and osteoblast activity. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:247–253, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21010