K. Mohamed, E. H. El-Sayed
2019
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HETEROCYCLES
Abstract
2-Cyano-N-(2,3-dihydro-1H-5-indenyl)-3-(dimethylamino)acrylamide (3) was used in synthetic paths to some novel indane-amide containing pyrazole, pyrimidine, fused pyrimidines, fused pyridines and 2-pyrone derivatives by reaction of 3 with various reagents. The newly synthesized compounds were investigated for their antioxidant activity. Some of the tested compounds exposed auspicious activities. INTRODUCTION Neuroprotective activity of aminoindane has a great attention because of its biological activity towards Alzheimer's disease or stroke. Also, acrylamide are privileged structures, which attracted significant attention in the designing of biologically active molecules. It's investigated and exhibited the various biological and pharmaceutical activities like antitumor, antimicrobial, analgesic, and antiinflammatory drugs. On the other hand, chromene derivatives has a great interest in the field of synthetic and medicinal chemistry, and displayed a lot of bioactivity such as bactericides, fungicides, anti-inflammatory, anticoagulant, anti-HIV therapy, dyes, and antitumor agents. In this context, join the fused heterocyclic compound and indane moietiy through a carboxamide linkage has been investigated. In view of the aforementioned findings, and as a continuation of our effort to identify new candidates that may be valuable in designing new, potent, selective, and antioxidant agents, we report herein a facile synthesis of novel fused heterocyclic compounds and the evaluation of their antioxidant agents. This combination was considered to study the biological significance to the target molecules. Based on the reported antioxidant activities of amides, we report here synthesis and