H. Gaffer, S. Abdel-fattah, H. Etman
2017
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0
Influential Citations
28
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
3-Methyl-1-thiocarbamoyl-2-pyrazolin-5-one has been utilized as a core for the synthesis of some 1-(thiazol-2-yl)-pyrazolin-5-one derivatives through diazo-coupling reaction and/or Knoevenagel condensation followed by heterocyclization with some α-halogenated reagents such as bromoacetone, phenacyl bromide, and ethyl bromoacetate. Base prompted addition of the core compound to an equimolar amount of phenyl isothiocyanate furnished 3-methyl-4-phenylthiocarbamoyl-1-thiocarbamoyl-2-pyrazolin-5-one which undergoes heterocyclization with α-halogenated reagents at the more reactive phenylthiocarbamoyl moiety to afford the corresponding 4-(thiazol-2-yl)-1-thiocarbamoyl-2-pyrazolin-5-ones. The new synthesized thiazolyl–pyrazolone compounds were evaluated for their potential antioxidant activity by using (ABTS Radical Cation Decolorization Assay).