G. Sravya, U. Nagarjuna, V. Padmavathi
Oct 23, 2019
Citations
0
Influential Citations
3
Citations
Quality indicators
Journal
Letters in Drug Design & Discovery
Abstract
A new class of 5-(styrylsulfonylmethyl)-1,3,4-oxadiazol-2-amine and 5- (styrylsulfonylmethyl)-1,3,4-thiadiazol-2-amine derivatives were prepared by derivatization of amino function. All the synthesized compounds were tested for antioxidant and anti-inflammatory activities. The 2-amino-3-chloro-N-(5-(4-methylstyrylsulfonylmethyl)-1,3,4-oxadiazol-2-yl)-propanamide (12b) and 3-chloro-N-(5-(4-methylstyrylsulfonylmethyl)-1,3,4-oxadiazol-2-yl)-butanamide (14b) displayed significant antioxidant activity, greater than the standard Ascorbic acid. Moreover, 12b and 14b also exhibited promising anti-inflammatory activity