M. Gouda, M. Berghot, Ghada E. Abd El-Ghani
Jul 1, 2016
Citations
1
Influential Citations
15
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
One-pot condensation of malononitrile 1, furan-2-carbaldehyde 2, butan-2-one 3, and ammonium acetate in ethanol, followed by cyanoacetylation of the formed nicotinonitrile 4 with 3-(3,5-dimethyl-1H-pyrazol-1-yl)-3-oxopropanenitrile 5 afforded the cyanoacetamide 6. Compound 6 was used as a key intermediate for synthesis of nicotinonitriles via reaction with different reagents.