V. Dianov
Jun 1, 2007
Citations
0
Influential Citations
6
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
Abstract3-Aminomethyl-substituted thiazolo[3,2-a]benzimidazoles were synthesized by reacting 3-(chloromethyl) thiazolo[3,2-a]benzimidazole with primary and secondary amines. The resulting 3-amino-derivatives of thiazolobenzimidazole were tested in vitro for antioxidant properties in relation to the autooxidation of adrenaline to adrenochrome. All the compounds studied inhibited, to different extents, the oxidation of adrenaline to adrenochrome, thus preventing formation of the superoxide radical.