I. Dvornikova, E. V. Buravlev, I. V. Fedorova
May 1, 2019
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Influential Citations
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Journal
Russian Chemical Bulletin
Abstract
A series of new 2-substituted-1H-benzimidazoles was synthesized on the basis of 4-hydroxybenzaldehydes. Their antioxidant properties were evaluated in the in vitro models and compared with those of known analogs. The structural specifi c features of the molecules responsible for the high antioxidant activity were revealed. Among tested derivatives, 2-substituted 1H-benzimidazole containing a phenol fragment with isobornyl and tert-butyl groups was found to have the greatest ability to protect biomolecules and cells under conditions of acute oxidative stress.