Yeh‐long Chen, Huan-Chin Lin, Chia-Ning Yang
Feb 1, 2008
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0
Influential Citations
10
Citations
Quality indicators
Journal
Chemistry & Biodiversity
Abstract
A series of 27 differently substituted 4‐anilinofuro[2,3‐b]quinolines were synthesized and evaluated for their antiproliferative activities against the HeLa, SKHep1, SAS, AGS, A549, and CE81T cell lines, cancers commonly found in Asian countries. Among the compounds tested, 1‐{4‐[(3‐chloro‐7‐methoxyfuro[2,3‐b]quinolin‐4‐yl)amino]phenyl}ethanone (1) was the most potent, with IC50 values of 3.1, 3.0, and 4.2 μM, resp., against the growth of HeLa, SKHep, and CE81T cells. Compound 1 was, thus, further evaluated by flow cytometry to evaluate its effect on the cell‐cycle distribution of HeLa cells. Our results indicated that 1 readily induces cell‐cycle arrest in the G2/M phase, followed by DNA fragmentation and, ultimately, cell death.