Xu-Ning Wei
2011
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Journal
Chemical Journal of Chinese Universities-chinese
Abstract
Pyrimidine plays important roles in pesticide innovation research and pyrimidine sub-structure can be easily found in fungicides,herbicides and insecticides or miticides,etc.As this ring can be easily modified,which makes it more reachable to design and synthesis novel bio-active heterocycle compounds from some pyrimidine structures.Based on our previous studies on pyrimidine and purine,three series of novel poly-substituted pyrimindine 5-amino derivatives(4) were designed and obtained with high yields using 2-N,N-diethylamino-4-chloro-5-nitropyrimidine(1) as starting material via substitution,reduction and acylation procedures in turn.The bioassay results indicate that nearly all the target compounds process good anti-TMV activity,but no herbicidal or fungicidal activities.Among them,compound 4l exhibits the highest inhibition value,which is higher than that of the positive control virazole(ribavirin) at the same concentration.