G. K. Rao, R. Subramaniam
May 9, 2015
Citations
1
Influential Citations
13
Citations
Quality indicators
Journal
Chemical Science
Abstract
A novel series of 3-chloro-N-(4-oxo-2-arylquinazolin-3(4H)-yl)-1-benzothiophene-2-carboxamide analogs derived from 3-amino-2-arylquinazolin-4(3H)-one have been synthesized in good yields and characterized by IR, 1HNMR, mass spectral and elemental analyses. All the compounds were evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative bacteria and were also screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue method. The compounds 3b and 3h showed good antitubercular and the compound 3a exhibited good antibacterial activity.