S. Ahmed, O. Ahmed, A. Abdelhamid
Jun 30, 2014
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Journal
European Journal of Chemistry
Abstract
Condensation of 1 H -1,2,4-triazol-5-amine with the appropriate sodium ( E )-(2-oxocycloalkylidene)methanolate gave 7,8-dihydro-6 H -cyclopenta[ e ][1,2,4]triazolo [1,5- a ]pyrimidine, 6,7,8,9-tetrahydro-[1,2,4]triazolo[1,5- a ]quinazoline, 7,8,9,10-tetra hydro-6 H -cyclohepta[ e ][1,2,4]triazolo[1,5- a ]pyrimidine and 6,7,8,9,10,11-hexahydro cycloocta[ e ][1,2,4]triazolo[1,5- a ]pyrimidine. Structures of the newly synthesized compounds were elucidated via elemental analyses, spectral (IR, 1 H NMR, 13 C NMR, 2D NMR), and X-ray single crystal diffraction data. These derivatives showed potent anti-tumor cytotoxic activity in vitro using different human cancer cell lines.