Xiong Jing
2011
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Journal
Chemistry World
Abstract
(S)-Methyl 2-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)-3-(4-hydroxy phenyl)propanoate and(R)-ethyl 2-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)-3-(4-hydroxyphenyl)propanoate were synthesized from L-tyrosine methyl ester and D-tyrosine ethyl ester,respectively,with EDCI/HOBt as a coupling reagent and 5-flurouracil-1-yl acetic acid as an intermediate.The corresponding acid enantiomers were obtained after hydrolysis.The structures of the compounds were characterized by 1H NMR,13C NMR,IR,MS,specific rotation measurement and etc.The in vitro antitumor activity tests indicated that the compounds have certain selective anti-tumor activities,in which the R-configuration may also made a contribution.