Li Tian-ca
2014
Citations
0
Influential Citations
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Citations
Quality indicators
Journal
Chinese Journal of Synthetic Chemistry
Abstract
5-Substituted-3,4-dibromo-2( 5H)- furanones( 5a,5d and 5g) were prepared by a threestep reaction from furfural and menthol( 3a) [or borneol( 3d),methanol( 3g) ]. A highly efficient and simple synthesis of a series of novel 2( 5H)-furanone derivatives( 7a ~ 7j) containing dithiocarbamate were first reported by one-pot reaction of secondary amines,CS2and 5 under without catalyst and solvent-free conditions. The structures were characterized by1H NMR,13C NMR and IR. The in vitro anti-Hela activities of 5-( S)-5-( l-menthyloxy)-3-bromo-4-( N-methyl-N'-benzyldithiocarbamate ester)-2( 5H)-furanone( 7c) were investigated by MTT method. The results showed that 7c exhibited the best inhibition activities against A459 with IC50of 0. 14 μM.