H. Okada, T. Koyanagi, N. Yamada
Sep 25, 1991
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0
Influential Citations
21
Citations
Quality indicators
Journal
Chemical & pharmaceutical bulletin
Abstract
Seventy novel benzoylphenylurea compounds were synthesized and their antitumor activities were examined in vivo against P388 leukemia. N-(2-Nitrobenzoyl)-N'-[4-(2-pyrimidinyloxy)phenyl]ureas showed the highest antitumor activities when dosed intraperitoneally or orally. Their structure-activity relationships were examined with particular focus on the position and the variety of substituent on each aryl ring.